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desvenlafaxine will enhance the amount or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) decrease the CYP2D6 substrate dose by nearly fifty%; no dosage adjustment desired with desvenlafaxine doses 7 consecutive day